It depends on who you ask! I'd take a look at Dr. Fackler's research, complete with his "wound profiles" showing approximately what each type of round will do to you insides. It's really a function of how much tissue is destroyed, which in turn depends on the diameter and depth of the hole. A .45 FMJ will punch a good-size hole and penetrate more than enough. Expanding ammo is even better, as you give up some of the excessive penetration for greater diameter.
The .223 is a different matter. Military FMJ will do nasty damage in close, because at high velocity the round will tumble and fragment, ripping a hole in the target that is pretty big relative to the size of the bullet. Expanding .223 will probably do even better. I imagine lightweight, ballistic-tip varmint rounds might be great for close-in defense in .223, but that's just my conjecture.
The .223 is a different matter. Military FMJ will do nasty damage in close, because at high velocity the round will tumble and fragment, ripping a hole in the target that is pretty big relative to the size of the bullet. Expanding .223 will probably do even better. I imagine lightweight, ballistic-tip varmint rounds might be great for close-in defense in .223, but that's just my conjecture.