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The Firearms Tactical Institute conducted a ballistics test on these rounds. You can read about it at
http://www.firearmstactical.com/tacticalbriefs/volume3/number2/article2.htm

As you can see, the rounds only penetrate in gelatin about 8" or so. This, combined with the small projectiles that are the result of fragmentation, make the round a poor choice for self defense purposes.
 
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