Quality and accuracy-wise the Python is the "Rolls Royce" of the revolver world.
The Python is basically a custom built revolver, completely hand assembled and fitted, and has a hand polished exterior finish.
ON THE AVERAGE, a Python is the most accurate production DA revolver ever built, and was intended from the get-go to be the finest DA revolver ever built.
Like a horribly expensive Italian sports car, it isn't for everyone, and it can't be abused like lesser guns can, and still function.
The Colt Trooper Mark III was Colt's replacement for the older style guns which had the same action as the Python.
When it simply got too expensive to build hand made revolvers, Colt designed the Trooper Mark III action.
The Trooper Mark III action is a transfer-bar ignition system, with internal parts made of a fore-runner of Metal Injection Moulding (MIM), known as "Sintered Steel".
The Trooper Mark III was later upgraded with a "short action" design hammer and trigger, a vented barrel, and a more rounded grip frame, and was named the Trooper Mark V.
In the Mark V, the hammer and trigger were changed to cast steel.
In the mid-1980's, the Trooper Mark V was fitted with a new design vented and ribbed barrel, made in stainless steel, and sold as the King Cobra.
These later Colt guns are absolute TANKS.
Master gunsmith Jerry Kuhnhausen thought these were the strongest mid-frame revolvers ever built, mostly due to Colt's superior forged and heat treated frames and cylinders.
If these guns have ANY weakness, it's the firing pin.
It's "possible" a few firing pins "may" be too hard, and "might" break if the gun is dry fired too much.
If you do break a firing pin, it's a factory ONLY replacement.
To replace the firing pin, a special press, press punches, and support jigs are needed to remove and replace the firing pin bushing, and a special tool is needed to re-stake the bushing rivet.
Unless these special tools are used, the frame can be seriously damaged, or even ruined.
The "fix" for any firing pin issues, is to simply use snap caps when dry firing.
Other than that, These later Colt's are very high-quality guns.
From my personal experience dealing with them, seeing how the actions stand up to use, and the internal and external fit and finish, I rate them as about 1/2 step above the S&W 686, a full step above the Ruger GP-100, and head and shoulders above the Taurus.
So, I'd put the Python as the sports car, and the Trooper Mark III, Mark V, and King Cobra as a Hummer.