I use good centerless ground two piece guide rods and I do not have problems with them coming loose. If you are going to use loctite on your guide rod I recommend the blue it should hold better then green loctite and will be much easier to take the rod apart then when using the red loctite.
I tighten my rods firmly and when doing this make sure the gun is fully assembled as you do not want to turn the recoil shield upside down they are a real pain to flip back over.
Also make sure the recoil shield has the proper bevel on the back side I find a lot rods have been installed in guns with out this being done.
Regards, Bob Hunter www.huntercustoms.com