Someone gave me 300rnds of handloads using the 250gr RNFP. I was impressed with how managable the recoil cycle was, and think the theory of a heavy bullet and light powder charge deserves more research. However, that particular bullet isn't designed for an autoloader, and trying to find the correct OAL might prove frustrating. The ogive is too wide, so even with a short OAL, the bullet is still too long where it matters. It may work, and it may not. As long as you don't loose confidence in your pistol's reliability then I guess nothing is harmed by experimenting.
JM