Well, the .22 TCM (and 5.56x24) generally shoots 40 grain bullets and within 50 yards - from a handgun will easily take out deer or hog. Deer fall best to the factory bullet, but I prefer the Speer 40gr Spire point for hogs because it has a much thicker jacket and will easily shatter ribs and skulls. One reason the TCM and by extension the 5.56x24 are so effective is the little bullets hold together very well and tend to deform into ball-shapes which share the energy wealth but keep the core intact for surprising penetration. The Speer 46gr JFP is also great for hogs for shooting from the front - up close. They tend to "turn in" when striking skull bone at an angle due to the flat nose and large meplat.
I saw a pig shot from too much angle where the bullet struck the haunch. Rather than run away, the porker's "hind end" dropped and flopped as he tried to scramble away with three working legs before a second shot entered behind the ear and he went silent. Later we found the Speer 40gr Spire point with it's thick jacket and small exposed tip had completely pulverized the "ball" of the hip joint and carried fragments further into the abdominal cavity. Though not a kill shot, it planted the animal on the spot for a quick finishing shot.
So I would expect the 10mm using Civil Defense to get the job done as well as long as it doesn't have to go through much bone to get into the juicy parts. The bullet is designed to fracture leaving the base to travel forward but just as with shotgun pellets, as chunks of bullet leave the initial mass, energy is instantly lost limiting penetration and the power to break bone. Taken close in on a side or rear quartering shot the CD bullet will easily defeat the rib cage and do a lot of damage just inside the chest cavity with enough to penetrate the heart if the shot hits right. I don't think it would be my first choice for hogs due to the fragmenting bullet - too much potential for fragmenting on the skull without making it through.
Another thought for the 10mm is to use the Lehigh Defense Xtreme Defender load from Underwood or make your own. For deer chose the lightest bullet option - 100gr. and you'll be impressed with the results to say the least. At "pistol distances" the solid copper slug easily shatters bone and creates an impressive wound channel. With the Xtreme Defender you choose a penetration depth then load to the velocity that gets you there with no worries about the effects of bullet expansion negatively affecting penetration. When they first introduced this bullet design they started out much heavier with smaller flutes and a larger tip cruciform. Then they discovered the things would penetrate "forever" and introduced much lighter (for caliber) versions with larger flutes and thin "blades" on the nose cruciform. This reduced penetration in favor of greater energy transfer.