loc-tite does work great. I actually used it on my little Walther P-22. A screw kept loosing up but it was one I dont ever plan on removing. Just be careful. Once it sets the screw may be difficult to remove, especially if you want to change the grips
I use the purple LocTite for removable and adjustable thread applications. 1 application and the grips can be removed for cleaning and reinstalled repeatedly. The screws stay where they're supposed to.
I have used bow string wax to very good effect in this area. I got this idea from a freind when shooting archery. It keeps the feild points from coming loose.Works great fore grip screws as well. Has for me anyhoo.
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