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The best load I've ever found for the .45 Colt is as follows: 250 gr. RNFP lead of 1:20 tin/lead alloy over 8.6 gr. of VV N32C Tin Star in Starline brass. That yields 875 fps in a 7.5" barrel, about 850 in a 4". It is ballistically identical to the original 1873 vintage black powder load. Like the BP load, it has 100% case fill, so ignition and velocity are very consistent and reliable. If you want a slightly less powerful load suitable for Cowboy matches, I would use a 230 gr. RNFP lead (same alloy) over 8.0 gr. of Tin Star in .45 Colt brass. That would give the equivalent of the original .45 Schofield load.

Both of the above bullets can be gotten from CowboyBullets.com, and are available in .452 or .454" sizing. Btw, the 1:20 alloy is the same as that used by the factory in the black powder days.
 
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