A lot of talk centers around the "dopers" who don't go down. Let's clear that up a little.
Illicit drugs can be put into the following categories:
1.) DEPRESSANTS---This is alcohol (yes, alcohol is a drug), barbituates, marijuana, and diazepams. There are more, but those are the most popular.
2.) STIMULANTS---This is amphetamine, methamphetamine, cocaine and its derivatives (i.e. "crack"), caffeine, and some of the so-called "designer drugs" such as ecstacy.
3.) HALLUCINOGENS---This is LSD, PCP, ketamine, psilocybic mushrooms, and mescaline.
4.) NARCOTICS---These are the highly addictive derivates of opium which include heroin, morphine, and laudanum.
Again, this is not a comprehensive list, just a list of the commonly-on-the-street drugs.
Now, out of the DEPRESSANTS category, someone under the influence of alcohol is the most likely to suffer a wound he might not be immediately incapacitated by. And alcohol is legal, so the likelihood of encountering someone under its influence is quite high. Another note: Among ALL drugs, alcohol is by far among the most dangerous to get into a confrontation with someone under the influence of. And, contrary to the teachings of such ridiculously naive movies as "Reefer Madness", someone under the influence of marijuana is probably less of a threat than someone stone, cold sober. Now among stimulants, methamphetamine is the worst-case scenario to encounter someone on. This is followed by cocaine. This is because it creates a false sense of invincibility in its user that actually transcends pain. Bear in mind, cocaine was once used by the natives of Peru to combat hunger pain, and amphetamine derivates were used by German troops on the Eastern Front in WW2 to still them in the face of Soviet "human wave" assaults. The likelihood of encountering someone under the inflence of methamphetamine is growing by leaps and bounds every day. Methamphetamine is among the most dangerous to encounter someone on BECAUSE the drug causes extreme paranoia, delusions of being threatened, irrationality, and stimulates violent tendencies. The "designer"drugs are growing in use daily and some can certainly lead to irrational, and therefore, dangerous behavior. Now, among the HALLUCINOGENS, PCP is the one that is the "classic" drug of people in the "shot twenty times and kept coming" incidents everyone is referring to these days. Among some, it is believed that it was the availability of this drug which lead to police departments abandoning the .38 Special. PCP, originally, was a tranqilizer for dangerous, wild animals such as tigers, rhinos, and elephants. As it was never intended for human use, its effects are, not suprisingly, quite opposite from its effects on large animals. Referred to as "angel dust", this is the ne plus ultra of dangerous drugs. It probably sits at the very top of the top five most dangerous drugs to encounter someone on. The likelhood of encountering someone on it is not nearly as great as encountering someone on meth or alcohol, but he who encounters someone on PCP is in a potential world of deep excrement ecause it is absolutely true: people uder the influence of PCP have actually been shot multiple times wthout going down. This is a real "night of the living dead" drug. Most of the other hallucinogens are not threatening as the users are by and large incapacitated by the drug itself. Peyote does not (contrary to the BS writings of Carlos Casteneda) cause people to act in a violent manner; on the contrary, peyote is used as a Sacrament in Native American Church Ceremonies and there are no adverse effects. Ketamine is pretty new, so it may or may not be a dangerous one to encounter someone on (but being a "synthetic", it probably might be a dangerous one.) Mushrooms are relatively benign as far as halluciogens go and are more likely to incapacitate the user during the duration of their use. LSD can be dangerous if the quantities are not strictly measured. Being as street drugs are not precise, yes, it can be dangerous to encounter someone under its influence. Now with the NARCOTICS, the problem is that they are painkillers. Bear in mind, this is what they give to someone who has lost an arm or leg or suffered serious injury. Being as a person under its influence is already deadened to pain, inflicting more won't bother him much. But on the flipside of the coin, it tends to be a soporific, so there won't be any feats of superhuman strength such as go along with PCP users.
Summarized, the drugs most likely to create kockdown problems are as follows:
1.) PCP
2.) METHAMPHETAMINE
3.) ALCOHOL
4.) COCAINE
5.) SYNTHETICS
Being as alcohol is more common, it is, by far, the biggest threat.
Now, in such cases, it is arguable as to whether or not a bigger caliber is better. But, the truth is, when hunting dangerous game, hunters still opt for the bigger calibers. That is, a larger mass might open more tissue, cause more bleeding, and have more potential to strike an organ or the spinal column. I think that if I knew for a fact I was facing a person under the influence of a dangerous drug, I'd want a 12 gauge shotgun. Or my .44 Magnum or my .45, if not both. That's based on what I know about the effects of these drugs on people.
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Those that beat their swords into plowshares will plow for those that don't