I second the vote for the XL 650. When I started reloading, I did so with a small single stage press. Cases were prepped by hand, and powder was hand weighed--each and every charge. Loading one box of .44 Magnum (my first caliber) was a significant undertaking.
Fast forward 15 years, to where I am now. A room stuffed full of reloading equipment, along with the crown piece, the Dillon 650. This machine is the cat's pajamas IMHO, with the possible exception of the new Super 1050 (Homer Simpson type drool here)--oooooaaaaaahhaaaaaaaaaaaa...........
The ways to speed up production with the 650 are as follows:
1. Buy seperate charge bars, and install each of them in your powder measure, adjusting each for your specific charge. Mark them well.
2. Seperate primer feed units, for large and small primers.
Beyond that, I believe it's a simple matter of practice. I clean the press every month or so, but can change calibers pretty fast, in about 10 minutes or so. Less than that if I'm using the same shell plate, and primer feed, such as my three favorites: .45 ACP, .30-06, and .308.
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"Be not afraid of any man, no matter what his size;
When trouble rises, call on me and I will equalize."