OP that is a good chart and very informative to all 45 enthusiast the first time they look at it...For me, I mostly shoot 21 to 25Y...Less than 21 is a waste of ammo, 25y is plenty to really test fundamental's...A few times a year, I shoot at the 50y pit. Little to do with SD, but it is fun and challenging, stressing the fundamentals even more than 25y. I don't make any consideration for the 2" drop with 45. I mostly shoot freehand, and I find the variation in my hold, wobble, is the key determinate in where the round will hit on the target. When I shoot off a rest occasional, I don't see any impact of the drop and are able to get nice tight groups. Never shot pistol at 100y, where there is some practical aspect of 50y shooting for me, personally I don't have any at 100y based on (my) SD lifestyle, and not in 45 (where the drop is so substantial). In say super and 357, I may give it a go at 100 some time (just for fun). As some other mentioned, depends where you want to focus your time, ammo, energy, to best serve your needs.