Are we talking about bullseye or defense? As a long time accomplished shooter, and not bragging, if I am shooting bullseye I'll opt for the 6 hold. If it's defense it will be a center hold. When you think of it, there is only a few inches of difference and most shooters can't do it anyway? 25 yards and precision shooting, or 50 yards precision, for me it is easier to do a 6 hold so I can see the sights more clearly. No black target to "fuzz" my sights.
If its self defense and inside of 25 yds, you are going to be history and DRT.
But, it has to be said that I have shot more than a million rounds of just the 45acp in practice and competition.
YMMV
Semper Fi
RK